Sleeping pill sales increased by 23% from 2006-2010 and generated about $2 billion in annual sales. Sleeping pills (including Ambien and Restoril) are linked to a 4.6 times higher risk of death and a significant increase in cancer. Among patients who were prescribed just 1-18 sleeping pills per year, the risk of death was 3.6 times higher. Rates of new cancers were 35% higher among patients who were prescribed at least 132 doses a year, compared with those who did not receive prescriptions.
BMJ Open, March 2012